ENDO-1 Enzyme


Mutation Discovery Tools
for Plant Science
for Animal and Human Genetics
for Bacteria identification

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Endo-1 is an endonuclease that cleaves specifically mismatches in heteroduplex DNA.           
Denaturation and renaturation of a mixture of DNAs from mutant and WT will create mismatches. The enzyme will cleave the mismatch and you will observe the digestion products (smaller fragments).

Endo-1 works at neutral pH in presence of Zn, with a proven superiority over other endonucleases. This enzyme is a diagnostic tools to discover new mutations (SNP, Ins/Del) in DNA and is the perfect enzyme for TILLLING™ reactions.

Download our Product and Protocol sheet (pdf format, 420 kb) or a poster (pdf format, 520 kb).

To order or to enquire for price: endo-1@serialgenetics.com

Notice to Purchasers: Limited Licence
This product is sold under licensing arrangements under the patent No PCT/EP2005/009220 with INRA (French National Institute for Agricultural Research) and GENOPLANTE-VALOR. The purchase price of this product includes limited, non-transferable rights to use only the product to detect DNA mismatches and related processes described in said patent where such processes are covered by patent solely for the research and development activities of the purchaser. Serial Genetics cannot guarantee that any use of the product for in-house research and development may not require additional licence(s) to third parties, e.g. in case of a third party’s patent that could be infringed by such use. The purchaser is not allowed to perform or offer commercial services of any kind using this product, where the process is covered by patent, including without limitation reporting the results of purchaser's activities for a fee or other commercial consideration. Further information on purchasing licenses to perform or offer commercial services where the process is covered by patent may be obtained by contacting INRA Transfert, 10 rue Vivienne, 75002 Paris, France (www.inra-transfert.fr). The purchaser undertakes to use this product according to the national and international laws and regulations and will make his business of obtaining all authorisations needed to the conduct of its research.